Wei | Yu

Education

Awards

2004-2005 Fellowship, National Kidney Foundation

2001-2004 Fellowship, American Heart Association

Publications

Choe JH, Watchmaker PB, Simic MS, Gilbert RD, Li AW, Krasnow NA, Downey KM, Yu W, Carrera DA, Celli A, Cho J, Briones JD, Duecker JM, Goretsky YE, Dannenfelser R, Cardarelli L, Troyanskaya O, Sidhu SS, Roybal KT, Okada H, Lim WA.SynNotch-CAR T cells overcome challenges of specificity, heterogeneity, and persistence in treating glioblastoma.

Sci Transl Med. 2021 Apr 28;13(591):eabe7378

Hernandez-Lopez RA, Yu W, Cabral KA, Creasey OA, Lopez Pazmino MDP, Tonai Y, De Guzman A, Mäkelä A, Saksela K, Gartner ZJ, Lim WA.T cell circuits that sense antigen density with an ultrasensitive threshold.Science. 2021 Mar 12;371(6534):1166-1171

Huang X, Williams JZ, Chang R, Li Z, Burnett CE, Hernandez-Lopez R, Setiady I, Gai E, Patterson DM, Yu W, Roybal KT, Lim WA, Desai TA.DNA scaffolds enable efficient and tunable functionalization of biomaterials for immune cell modulation. Nat Nanotechnol. 2021 Feb;16(2):214-223

Williams JZ, Allen GM, Shah D, Sterin IS, Kim KH, Garcia VP, Shavey GE, Yu W, Puig-Saus C, Tsoi J, Ribas A, Roybal KT, Lim WA.Precise T cell recognition programs designed by transcriptionally linking multiple receptors.Science. 2020 Nov 27;370(6520):1099-1104

Yu W, Marshall WF, Metzger RJ, Brakeman PR, Morsut L, Lim W, Mostov KE.Simple Rules Determine Distinct Patterns of Branching Morphogenesis.Cell Syst. 2019 Sep 25;9(3):221-227

Bryant DM. Roignot J. Datta A, Overeem AW, Kim M, Yu W, Peng X, Eastburn DJ, Ewald AJ, Werb Z, and Mostov KE. Dev Cell. 2014 Oct 8. A Molecular Switch for the Orientation of Epithelial Cell Polarization.

Cerruti B, Puliafito A, Shewan AM, Yu W, Combes AN, Little MH, Chianale F, Primo L, Serini G, Mostov KE, Celani A, Gamba A.J Cell Biol. 2013 Oct 28;203(2):359-72.Polarity, cell division and out-of-equilibrium dynamics control the growth of epithelial structures

Kim SH, Yu W, Mostov K, Matthay MA, Hunt CA. (2009) A computational approach to understand in vitro alveolar morphogenesis. PLoS One. 4(3):e4819

Yu W, Fang X, Ewald A, Wong K, Hunt AC, Werb Z, Matthay MA, and Mostov K. (2007) Formation of cysts by alveolar type II cells in three-dimensional culture reveals a novel mechanism for epithelial morphogenesis. Molecular Biology of the Cell. 18:1963-1700.

Liu KD, Datta A, Yu W, Brakeman PR, Jou TS, Matthay MA, Mostov KE. (2007)Rac1 is required for reorientation of polarity and lumen formation through a PI 3-kinase-dependent pathway. Am J Physiol Renal Physiol. 293(5):F1633-40.

Kim M, Datta A, Brakeman P,Yu W and Mostov K. (2007)Polarity proteins PAR6 and aPKC regulate cell death through GSK-3beta in 3D epithelial morphogenesis.

J Cell Sci. 15;1202309-17.

Yu W, Fang X, Ewald A, Wong K, Hunt AC, Werb Z, Matthay MA, and Mostov K. (2007) Formation of cysts by alveolar type II cells in three-dimensional culture reveals a novel mechanism for epithelial morphogenesis. Molecular Biology of the Cell. 18:1963-1700.

Martin-Belmonte F, Gassama A, Datta A, Yu W, Rescher U, Gerke V, and Mostov K. (2007) PTEN-mediated segregation of membrane phosphoinositides at the apical membrane controls epithelial mprphogenesis through Cdc42. Cell, 128:383-397.

Fan QW, Knight ZA, Goldenberg DD, Yu W, Mostov KE, Stokoe D, Shokat KM, Weiss WA. (2006) A dual PI3 kinase/mTOR inhibitor reveals emergent efficacy in glioma. Cancer Cell, 9(5):341-9.

Gassama A, Yu W, ter Beest M, Martin-Belmonte F, Kierbel A, Engel J and Mostov K. (2006) Phosphatidylinositol 3,4,5-trisphosphate regulates the formation of the basolateral plasma membrane in epithelial cells. Nature Cell Biology, 8(9):963-70.

O'Brien LE, Yu W, Tang K, Jou TS, Zegers MM, Mostov KE. (2006). Morphological and biochemical analysis of Rac1 in three-dimensional epithelial cell cultures. Methods Enzymol. 406:676-691.

Yu W, Datta A, Leroy P, O’Brien L, Jou T, Mak G, Matlin KS, Mostov K and Zegers M. (2005), ß1-integrin orients epithelial polarity via Rac1 and laminin. Molecular Biology of the Cell. 16:433-445.

Yu W, O’Brien L, Wang F, Bourne H, Mostov K, and Zegers M, (2003), Hepatocyte Growth Factor Switches Orientation of Polarity and Mode of Movement During Morphogenesis of Multicellular Epithelial Structures. Molecular Biology of the Cell 14:748-763.

Niki I, Niwa T, Yu W, Budzko D, Miki T, Senda T(2003), Ca2+ influx does not trigger glucose-induced traffic of the insulin granules and alteration of their distribution. Exp Biol Med 228(10):1218-26.

Yu W, Niwa T, Fukasawa T, Hidaka T, Senda T, Sasaki Y and Niki., (2000), Synergism of protein kinases A, C and myosin light chain

Yu W,Nakamura A, Nakahari H, Imai Yand Senda T. (1998), Classification of the frog lingual gland and their exocytotic features. J of Electron Microscopy, 47(1):73-80.

Yu W, Niwa T, Fukasawa T, Hidaka T, Senda T, Sasaki Y and Niki., (2000), Synergism of protein kinases A, C and myosin light chain kinase in the secretory cascade of the pancreatic beta-cells. Diabetes. 49:945-952.

Niwa T, Fukusawa T, Yu W, Nimura Y, Senda T, Ohgawara H and Niki I. (2001), Charaterization of secretory and morphologic properties of primary cultured endocrine cells from porcine pancreata. Pancreas.22(2):135-140.

Fan QW, Yu W, Senda T. Yanagisawa K and Michikawa, M, (2002), Cholesterol-dependent modulation of dendrite outgrowth and microtubule stability in cultured neurons. J. Neurochem 80:178-190.

Fan QW, Yu W, Senda T, Yanagisawa K and Michikawa M., (2001), Cholesterol-dependent modulation of tau phosphorylation in cultured neurons. J Neurochem Jan;76(2):391-400.

Senda T and Yu W., (1999), Kinesin cross-bridge between neurosecretory granules and microtubules in the mouse neurohypophysis. Neuroscience Letters.262:69-71.