Toshimichi | Yamada


Postdoctoral Fellow



Department of Chemistry, Graduate School of Science, University of Tokyo
Advisor: Takeaki Ozawa


University of Tokyo

Research Interests

Understanding design principles of development


2020-2021 TOYOBO Biotechnology Fellowship

2017-2019 JSPS Research Fellowship for Young Scientists, PD

2012-2015 JSPS Research Fellowship for Young Scientists, DC1


T. Yamada N. Imamachi, K. Imamura, K. Taniue, T. Kawamura, Y. Suzuki, M. Nagahama, N. Akimitsu "Systematic Analysis of Targets of Pumilio-mediated mRNA Decay Reveals that PUM1 Repression by DNA Damage Activates Translesion Synthesis" Cell Reports, In press

T. Yamada, N. Akimitsu "Contributions of regulated transcription and mRNA decay to the dynamics of gene expression" Wiley Interdisciplinary Reviews: RNA, 10, e1508, 2019.

K. Imamura, ..., T. Yamada,..., Y. Suzuki, M. Nagahama, T. Yamamoto, T. H. Jensen, N. Akimitsu “Diminished nuclear RNA decay upon Salmonell a infection upregulates antibacterial noncoding RNAs” The EMBO journal, 37, e97723, 2018

T. Yamada, N. Imamachi, R. Onoguchi-Mizutani, K. Imamura, Y. Suzuki, N. Akimitsu “5’-Bromouridine IP Chase (BRIC)-Seq to Determine RNA Half-Lives” Methods in Molecular Biology, 1720, pp1-13, 2018.

T. Yamada, H. Yoshimura, R. Shimada, M. Hattori, M. Eguchi, T. K. Fujiwara, A. Kusumi, T. Ozawa “Spatiotemporal analysis with a genetically encoded fluorescent RNA probe reveals TERRA function around telomeres” Scientific reports, 6, 38910, 2016

T. Nishiguchi, T. Yamada, Y. Nasu, M. Ito, H. Yoshimura, T. Ozawa “Development of red-shifted mutants derived from luciferase of Brazilian click beetle Pyrearinus termitilluminans” Journal of Biomedical Optics, 20, 101205, 2015

K. Imamura, ... , T. Yamada, T. Ozawa, ..., T. Kodama, Y. Wada, K. Sekimizu, N. Akimitsu “Long noncoding RNA NEAT1-dependent SFPQ relocation between nuclear body paraspeckle and promoter mediates IL8 expression in response to immune stimuli.” Molecular Cell, 53, pp393-406, 2014

H. Yoshimura, A. Inaguma, T. Yamada, T. Ozawa “Fluorescent probes for imaging endogenous β-actin mRNA in living cells using fluorescent protein-tagged pumilio” ACS Chemical Biology, 7, pp999-1005, 2012

T. Yamada, H. Yoshimura, A. Inaguma, T. Ozawa “Visualization of Nonengineered Single mRNAs in Living Cells Using Genetically Encoded Fluorescent Probes” Analytical Chemistry, 83, pp5708-5714, 2011

M. Takeuchi, Y. Nagaoka, T. Yamada, H. Takakura, T. Ozawa “Ratiometric Bioluminescence Indicators for Monitoring Cyclic Adenosine 3’,5’-Monophosphate in Live Cells Based on Luciferase-Fragment Complementation” Analytical Chemistry, 82, pp 9306–9313, 2010.