Rogelio | Hernandez-Lopez

Education

Research Interests

Next-generation T cell therapies for cancer treatment: Antigen density sensors

Science education and outreach in Mexico and Latin America

Awards

2021-2024 Burroughs Wellcome Fund Career Award at the Scientific Interface

2020 The American Society for Cell Biology Public Engagement Award

2017-2021 Merck Postdoctoral Fellowship (Cancer Research Institute)

2016 Postdoctoral Fellowship (UC MEXUS)

2012 Christensen Prize for Outstanding Research Achievement (Harvard University)

2010-2012 Fundacion Mexico en Harvard, Fellowship for Ph.D. degree

2010 Gabino Barreda Medal Class 2004 in Chemistry (Given to the top student in each class, UNAM, Mexico)

Publications

Hernandez-Lopez,R.A., Yu, W., Cabral, K.A.*, Creasey, O.A.*, Lopez Pazmino, M.P., Tonai,Y., De Guzman, A., Mäkelä, A., Saksela, K., Gartner, Z.J., Lim, W.A “T cell circuits that sense antigen density with an ultrasensitive threshold”. Science (2021).

Huang, X., Williams, J.Z., Chang, R, Li, Z., Burnett, C.E., Hernandez-Lopez, R., Setiady, I., Gai, E., Patterson, D.M., Yu, W., Roybal, K.T., Lim, W.A.#, Desai, T.A.# “DNA scaffolds enable efficient and tunable functionalization of biomaterials for immune cell modulation”. Nature Nanotechnology (2020).

Ludington, W.B., Ishikawa, H., Serebrenik, Y.V., Ritter, A.*, Hernandez-Lopez, R.*, Gunzenhauser,J.*, Kannegaard, E., and Marshall, W.F. “A systematic comparison of mathematical models for inherent measurement of ciliary length: how a cell can measure length and volume”. Biophysical Journal (2015).

Ramirez-Cordero, B. , Toledano, Y., Cano-Sanchez, P., Hernandez-Lopez, R., Flores-Solis, D., Saucedo-Yanez, A, Chavez-Uribe, I., Brieba de Castro, L., and del Río-Portilla, F. “Cytotoxicity of recombinant tamapin and related toxin-like peptides on model cell lines”. Chemical research in toxicology (2014).

Gurrola Briones, G., Hernandez-Lopez, R., Rodriguez de la Vega, R., Varga, Z., Ferreira Batista, C., Salas-Castillo, S., Panyi, G., Del Rio-Portilla, F., and Possani, L. D. “Structure, function and chemical synthesis of Vaejovis mexicanus peptide 24: a novel potent blocker of Kv1.3 potassium channels of human T lymphocytes”. Biochemistry (2012).

RedwineW. B. *, Hernandez-Lopez, R.*, Zou, S., Huang, J., Reck-Peterson, S. L., and Leschziner, A. E. “Structural basis for microtubule binding and release by dynein”. Science (2012).

Saucedo-Yanez, A., Flores-Solis, D., Rodriguez de la Vega, R., Ramirez-Cordero, B., Hernandez-Lopez, R., Cano-Sanchez, P., Noriega-Navarro, R., Garcia-Valdez, J., Coronas-Valderrama, F., de Roodt, A., Brieba de Castro, L., Possani, L. D., and del Río-Portilla, F. “New tricks of an old pattern: structural versatility of scorpion toxins with common cysteine spacing”. The Journal of Biological Chemistry (2012).

Chandramouli P., Hernandez-Lopez, R., Wang, H., and Leschziner, A. “Validation of the orthogonalt tilt reconstruction method with a biological test sample”. Journal of Structural Biology (2011).

* Equal contribution