Manish | Ayushman, PhD

manish.ayushman ucsf.edu

Postdoctoral Scholar

Education

2025-Present

Postdoctoral scholar
University of California, San Francisco

2019-2025

Ph.D., Bioengineering
Stanford University

2014-2019

B.Tech. and M.Tech., Chemical Engineering
Indian Institute of Technology (IIT), Kharagpur

Research Interests

Programming the extracellular matrix as a node in cell signaling circuits.

Awards

2021-2024 BioX Stanford Interdisciplinary Graduate Fellowship (SIGF)

2024 Stanford Bio-X Best Poster Award

2023 Student Travel Achievement Recognition Award, Society for Biomaterials

2022 Stanford Bio-X Star Mentor Award

2022 Stanford Bioengineering Teaching Assistantship Award

2022 Student Research Achievement Award, Biophysical Society

2018-2019 Institute Proficiency Award for best Bachelor's and Master's theses

2018 Certificate of Student Invention, IIT Kharagpur

2018 Khorana Scholar, Johns Hopkins University

2017 Bioengineering Summer Training Fellow, Indian Institute of Science

Publications

Sinha, S., Fleck, M.*, Ayushman, M.*, Tong, X., Mikos, G., Jones, S., Soto, L., Yang, F., "Matrix stiffness regulates GBM migration and chemoradiotherapy responses via chromatin condensation in 3D viscoelastic matrices", ACS Applied Materials & Interfaces, 2025, *equal contribution. doi: 10.1021/acsami.4c16993.

Villicana, C., Su, N., Yang, A., Tong, X., Ayushman, M., Lee, J., Lee, H., Kim, T., Yang, F. "Incorporating Bone-derived ECM into Macroporous Mineral-containing Microribbon Scaffolds Accelerates Endogenous Bone Regeneration", Advanced Healthcare Materials, 2025. doi: 10.1002/adhm.202402138.

Tong, X.*, Ayushman M.*, Lee, H.-P., Yang, F., “Tuning Local Matrix Compliance Accelerates Mesenchymal Stem Cell Chondrogenesis in 3D Sliding Hydrogels”, Biomaterials, 2025, *equal contribution. doi: 10.1016/j.biomaterials.2025.123112.

Ayushman, M., Lee, H.P., Agarwal, P., Mikos, G., Sinha, S., Tong, X., Jones, S., Sinha, S., Goodman, S., Bhutani, N., Yang, F. "Sliding hydrogels reveal the modulation of mechanosensing attenuates the inflammatory phenotype of osteoarthritic chondrocytes in 3D", Journal of Biomedical Materials Research: Part A, 2025, doi: 10.1002/jbm.a.37861.

Ayushman, M., Mikos, G.*, Tong, X.*, Sinha, S., Lopez-Fuentes, E., Jones, S., Cai, P., Lee, H., Morrison, A., Spakowitz, A., Heilshorn, S., Sweet-Cordero, A., Yang, F. “Cell Tumbling enhances stem cell differentiation in hydrogels via nuclear mechanotransduction”, Nature Materials, 2024, *equal contribution. doi: 10.1038/s41563-024-02038-0.

Sinha, S., Huang, M., Mikos, G., Singh, Y., Soto, L., Lensch, S., Ayushman, M., Bintu, L., Bhutani, N., Heilshorn, S., Yang, F. “Laminin-associated integrins mediate Diffuse Intrinsic Pontine Glioma infiltration and therapy response within a neural assembloid model.”, Acta Neuropathologica Communications, 2024. doi: 10.1186/s40478-024-01765-4.

Sinha, S., Ayushman, M., Tong, X., Yang, F. “Dynamically Crosslinked PEG Hydrogels Reveal a Critical Role of Viscoelasticity in Modulating Glioblastoma Fates and Drug Responses in 3D.", Advanced Healthcare Materials, 2023. doi: 10.1002/adhm.202202147.

Mukhopadhyay, M., Ray, R., Ayushman, M., Sood, P., Bhattacharyya, M., Sarkar, D., DasGupta, S. "Interfacial energy driven distinctive pattern formation during the drying of blood droplets", Journal of Colloid and Interface Science, 2020. doi: 10.1016/j.jcis.2020.04.008.

Sett, A., Ayushman, M., Dasgupta, S., DasGupta, S. "Analysis of the Distinct Pattern Formation of Globular Proteins in Presence of Micro and Nanoparticles", Journal of Physical Chemistry B, 2018. doi: 10.1021/acs.jpcb.8b05325.