Josiah | Gerdts

Education

2017 - present

2016 - 2017

2007 - 2016

Research Interests

Synthetic biology tools to study and perturb cellular interactions in the context of neurologic disease

Fellowships, Awards

2019 NIH R25 Fellowship (NINDS)

2015 Spencer T. and Ann W. Olin Fellowship

2014 Washington University O’Leary Prize for Excellence in Neuroscience Research

2012 Washington University Hope Center Award

2011 NIH F31 Ruth L Kirchenstein Pre-doctoral fellowship (NINDS)

2004 Wisconsin Hilldale research fellowship

Publications

Gerdts J ", Milbrandt J, DiAntonio A. Axon Self-Destruction: New Links among SARM1, MAPKs, and NAD+ Metabolism. Neuron. 2016 Feb 3;89(3):449-60"

Gerdts J ", Brace EJ, Sasaki Y, DiAntonio A, Milbrandt J. SARM1 activation triggers axon degeneration locally via NAD⁺ destruction. Science. 2015 Apr 24;348(6233):453-7"

Gerdts J ", Summers DW, Sasaki Y, DiAntonio A, Milbrandt J. Sarm1-mediated axon degeneration requires both SAM and TIR interactions. J Neurosci. 2013 Aug 14;33(33):13569-80."

"Bhattacharya MR, " Gerdts J ", Naylor SA, Royse EX, Ebstein SY, Sasaki Y, Milbrandt J, DiAntonio A. A model of toxic neuropathy in Drosophila reveals a role for MORN4 in promoting axonal degeneration. J Neurosci. 2012 Apr 11;32(15):5054-61."

Gerdts J ", Sasaki Y, Vohra B, Marasa J, Milbrandt J. Image-based screening identifies novel roles for IkappaB kinase and glycogen synthase kinase 3 in axonal degeneration. J Biol Chem. 2011 Aug 12;286(32):28011-8."

"Ferrazzano P, Shi Y, Manhas N, Wang Y, Hutchinson B, Chen X, Chanana V, " Gerdts J ", Meyerand ME, Sun D. Inhibiting the Na+/H+ exchanger reduces reperfusion injury: a small animal MRI study. Front Biosci. 2011 Jan 1;3:81-8."

"Luo J, Wang Y, Chen H, Kintner DB, Cramer SW, " Gerdts J ", Chen X, Shull GE, Philipson KD, Sun D. A concerted role of Na+ -K+ -Cl- cotransporter and Na+/Ca2+ exchanger in ischemic damage. J Cereb Blood Flow Metab. 2008 Apr;28(4):737-46."

"Kintner DB, Luo J, " Gerdts J ", Ballard AJ, Shull GE, Sun D. Role of Na+-K+-Cl- cotransport and Na+/Ca2+ exchange in mitochondrial dysfunction in astrocytes following in vitro ischemia. Am J Physiol Cell Physiol. 2007 Mar;292(3):C1113-22."