Lim Lab | Papers

How signaling proteins integrate multiple inputs: a comparison of N-WASP and Cdk2

Kenneth E. Prehoda and Wendell A. Lim
Current Opinion in Cell Biology14, 149-154 (2002)

Signal transduction proteins that can integrate multiple upstream signals play a critical role in the complex regulatory circuits that control cellular behavior. The two signaling node proteins cyclin-dependent kinase 2 and the actin regulator neuronal Wiskott-Aldrich syndrome protein have qualitatively similar signaling properties. Recent studies, however, reveal that these proteins utilize distinct mechanisms of signal integration, leading to subtle but important quantitative differences in behavior.