Lim Lab | Papers

Sending mixed messages for cell population control.

Hyun Youk and Wendell A. Lim
Cell 158: 973-975 (2014)

Cells often receive signals to proliferate, but how population density is controlled is unclear. Hart et al. now show that a single secreted molecule that instructs both proliferation and death in T cells establishes a bistable response: the population is driven to either extinction or to a homeostatically defined density.