Leonardo | Morsut

leonardo.morsut ucsf.edu

Postdoctoral Fellow

Education

2012 - present
Postdoctoral Fellow
University of California, San Francisco

2010 - 2011
Postdoctoral Fellow
University of Padova, Italy

2007 - 2010
PhD, Bioscience, Genetics and Molecular Biology of Development
University of Padova, Italy

2004 - 2006
B.S., Mathematics
University of Padova, Italy

1999 - 2004
B.S. & M.S., Medical Biotechnologies
University of Padova, Italy

Research Interests

Developing synthetic biology approaches for mammalian multicellular systems.

Current projects include:

Fellowships and Awards

NIH/NIBIB K99 Pathway to Independence Award (2015-Present)
HFSP postdoctoral long-term fellowship (2013-2015)
EMBO postdoctoral fellowship (2012-2013)
Telethon Foundation Study Prize (2010)
Poster Prize at the Spetses EMBO / FEBS Advanced Lecture Course "Molecular Mechanisms in Signal Transduction and Cancer" (Aug 2007)
Telethon Foundation Study Price (Dec 2006)
Academic seal from the University of Padua for the graduation thesis (2004)
"EISE 2004" Award for excellence in sport and education (2004)

Publications

Leonardo Morsut*, Kole T. Roybal*, Xin Xiong, Russell M. Gordley, Scott M. Coyle, Matthew Thomson, Wendell A. Lim. "Engineering customized cell sensing and response behaviors using synthetic notch receptors." Cell (Resource) (2016)

Kole T. Roybal, Levi J. Rupp, Leonardo Morsut, Whitney J. Walker, Krista A. McNally, Jason S. Park, Wendell A. Lim. "Precision tumor recognition by T cells with combinatorial antigen-sensing circuits." Cell (2016)

Gilbert, L.A., Larson, M.H., Morsut, L., Liu, Z., Brar, G.A., Torres, S.E., Stern-Ginossar, N., Brandman, O., Whitehead, E.H., Doudna, J.A., Lim, W.A., Weissman, J.S., Qi, L.S. "CRISPR-mediated modular RNA-guided regulation of transcription in eukaryotes." Cell (Resource) 154, 1-10 (2013).

Inui, M., Manfrin, A., Mamidi, A., Martello, G., Morsut, L., Soligo, S., Enzo, E., Moro, S., Polo, S., Dupont, S., Cordenonsi, M., Piccolo, S. "USP15 is a deubiquitylating enzyme for receptor-activated SMADs." Nature Cell Biology (Letter) 13 1368-75 (2011).

Dupont, S.*, Morsut, L.*, Aragona, M., Enzo, E., Giulitti, S., Cordenonsi, M., Zanconato, F., Le Digabel, J., Forcato, M., Bicciato, S., Elvassore, N., Piccolo, S. "Role of YAP/TAZ in mechanotransduction." Nature (Article) 474 179- 83 (2011). (*equal contribution)

Morsut, L., Yan, K.P., Enzo, E., Aragona, M., Soligo, S.M., Wendling, O., Mark, M., Khetchoumian, K., Bressan, G., Chambon, P., Dupont, S., Losson, R., Piccolo, S. "Negative control of Smad activity by ectodermin/Tif1gamma patterns the mammalian embryo." Development 137 2571-8 (2010).

Dupont, S., Mamidi, A., Cordenonsi, M., Montagner, M., Zacchigna, L., Adorno, M., Martello, G., Stinchfield, M.J., Soligo, S., Morsut, L., Inui, M., Moro, S., Modena, N., Argenton, F., Newfeld, S.J., Piccolo, S. "FAM/USP9x, a deubiquitinating enzyme essential for TGFbeta signaling, controls Smad4 monoubiquitination. Cell 136 123-35 (2009).

Martello, G., Zacchigna, L., Inui, M., Montagner, M., Adorno, M., Mamidi, A., Morsut, L., Soligo, S., Tran, U., Dupont, S., Cordenonsi, M., Wessely, O., Piccolo, S. "MicroRNA control of Nodal signalling." Nature (Article) 449 183-8 (2007).

Porzionato, A., Macchi, V., Morsut, L., Parenti, A., De Caro, R. "Microvascular patterns in human medullary tegmentum at the level of the area postrema." Journal of Anatomy 206 405-10 (2005).