Kole | Roybal

kole.roybal ucsf.edu

Postdoctoral Fellow

Education

2013 - present
Postdoctoral Fellow
University of California, San Francisco

2013
PhD, Immunology
UT Southwestern Medical Center at Dallas

2005
B.S.,Biology
Austin College

Research Interests

Development of synthetic and chemical biology approaches to control T cell activation

Fellowships and Awards

2013 Jane Coffin Childs Fund Postdoctoral Fellowship
2012 UT Southwestern Dean's Award for Academic and Research Excellence
2011 Eliot Golding's Award for Outstanding Graduate Student Thesis in the Department of Immunology
2007-2010 NIH - Ruth L. Kirschstein National Research Service Award

Publications

Roybal, K.T., Williams, J.Z., Morsut, L., Rupp, L.J., Walker, W.J., McNally, K.A., Lim, W.A. "Engineering T cells with Customized Therapeutic Reponse Programs Using Synthetic Notch Receptors". Cell (2016) Oct. 6; 167, 419-432.

Leonardo Morsut*, Kole T. Roybal*, Xin Xiong, Russell M. Gordley, Scott M. Coyle, Matthew Thomson, Wendell A. Lim. "Engineering customized cell sensing and response behaviors using synthetic notch receptors." Cell (Resource) (2016)

Kole T. Roybal, Levi J. Rupp, Leonardo Morsut, Whitney J. Walker, Krista A. McNally, Jason S. Park, Wendell A. Lim. "Precision tumor recognition by T cells with combinatorial antigen-sensing circuits." Cell (2016)

Roybal, K.T., Sinai, P., Verkade, P., Murphy, R.F., Wülfing, C. "The actin-driven spatiotemporal organization of T cell signaling at the systems scale." Immunol. Rev. 256(1) In press (2013).

Roybal, K.T. and Wülfing, C. "New TACTICS for finding Numb." Immunol. Cell Biol. 91, 1 (2013).

Falcon, E., Ozburn, A., Mukherjee, S., Roybal, K.T., McClung C.A. "Differential regulation of the period genes in striatal regions following cocaine exposure." PLoS ONE 8(6): e66438. doi:10.1371/journal.pone.0066438 (2013).

Eitson J., Medeiros, J., Hoover, A., Srivastava, S., Roybal, K.T., Ainsa, J., Hansen, E., Gumbo, T., van Oers, N.S. "Mycobacterial Shuttle Vectors Designed for High Level Protein Expression in Infected Macrophages." Appl. Environ. Microbiol. 78(19):6829-37 (2012).

Deford-Watts, L.M., Dougall, D.S., Belkaya, S., Johnson, B.A., Eitson, J.L., Roybal, K.T., Barylko, B., Albanesi, J.P., Wülfing, C., van Oers, N.S. "The CD3 {zeta} Subunit Contains a Phosphoinositide-Binding Motif That Is Required for the Stable Accumulation of TCR-CD3 Complex at the Immunological Synapse." J Immunol. 186:6839-6847 (2011).

Roybal, K.T. and Wülfing, C. "Inhibiting the inhibitor of the inhibitor: blocking PKC-theta to enhance regulatory T cell function." Sci Signal. 3(132):pe24 (2010).

Sinai, P., Roybal, K.T., Wülfing, C. "Tentative and transient natural killer cell polarization balances the requirements for discriminatory recognition and cytolytic efficacy." Commun Integr Biol. 3:545-548 (2010).

Singleton, K.L.*., Roybal K.T.*, Sun, Y., Fu, G., Gascoigne, N.R., van Oers, N.S., Wülfing, C. "Spatiotemporal patterning during T cell activation is highly diverse." Sci Signal. 2(65):ra15 (2009). (* equal contribution)

Roybal, K.T., Theobold, D., Graham, A., DiNieri, J.A., Russo, S.J., Krishnan, V., Chakravarty, S., Peevey, J., Oehrlein, N., Birnbaum, S., Vitaterna, M.H., Orsulak, P., Takahashi, J.S., Nestler, E.J., Carlezon, Jr., W.A., McClung, C.A. "Mania-like behavior induced by disruption of CLOCK." Proc Natl Acad Sci USA. 104:6406-6411 (2007).