Jonathan H. | Esensten


Postdoctoral Fellow


July 2015 - present
Postdoctoral Fellow
University of California, San Francisco

2012 - present
Department of Laboratory Medicine, UCSF

July 2014 - June 2015
UCSF-Blood Centers of the Pacific Transfusion Medicine/Blood Banking

2004 - 2012
Ph.D. (2010), M.D. (2012)
University of California, San Francisco Medical Scientist Training Program

2000 - 2004
A.B., magna cum laude in Biochemical Sciences
Harvard University

Research Interests

Development of synthetic and chemical biology approaches for T cell therapeutics.


2016-2019 Leukemia and Lymphoma Society Fellow

2013 Krevans Award in Laboratory Medicine

2010 Alpha Omega Alpha Honor Society


Wiita, A.P.; Hsu, G.W.; Lu, C.M.; Esensten, J.H.; Wells, J.A.; "Circulating proteolytic signatures of chemotherapy-induced cell death in humans discovered by N-terminal labeling." Proc. Natl. Acad. Sci. USA 111(21):7594-9 (2014)

Martínez-Llordella, M*; Esensten, J.H.*; Bailey-Bucktrout S.L.; Lipsky R.H.; Marini A.; Chen, J.; Mughal, M.; Mattson, M.P.; Taub, D.D.; Bluestone, J.A.; "CD28-inducible transcription factor DEC1 is required for efficient autoreactive CD4+ T cell response."" J. Exp. Med., 210(8):1603-19 (2013)

de Kouchkovsky, D.; Esensten, J.H.; Rosenthal W.L.; Morar, M.M.; Bluestone, J.A.; Jeker, L.T.; "microRNA-17-92 Regulates IL-10 Production by Regulatory T Cells and Control of Experimental Autoimmune Encephalomyelitis. Journal of Immunology (2013) Aug. 15; 191(4):1594-605

Bour-Jordan, H.; Esensten, J.H.; Martinez-Llordella, M.; Penaranda, C.; Stumpf, M.; Bluestone, J.A.; "Intrinsic and extrinsic control of peripheral T-cell tolerance by costimulatory molecules of the CD28/B7 family." Immunol. Rev. (2011) May 24; 241(1):180-205

McCLymont, S.A.; Putnam, A.L.; Lee, M.R.; Esensten, J.H.; Liu, W.; Hulme, M.A.; Hoffmüller, U.; Baron, U.; Olek, S.; Bluestone, J.A.; Brusko, T.M.; "Plasticity of human regulatory T cells in healthy subjects and patients with type 1 diabetes." J. Immunol. (2011) Apr. 1; 186(7):3918-26

de Kouchkovsky, D.; Esensten, J.H.; Bluestone, J.A.; Jeker, L.T.; "microRNAs induced by CD28 are required for optimal T cell co-stimulation and essential for Treg function in vivo." Keystone Conference (Immunoregulatory Networks, D5) Abstract and poster #213, April 2011.

Esensten, J.H.; Wofsy, D.; Bluestone, J.A.; "Regulatory T cells as therapeutic targets in rheumatoid arthritis." Nature Reviews Rheum. 2009 Oct; 5(10):560-5.

Esensten, J.H.; Lee, M.R.; Glimcher, L.H.; Bluestone, J.A.; "T-bet-deficient NOD mice are protected from diabetes due to defects in both T cell and innate immune system function." J Immunol. 2009 Jul 1; 183(1):75-82.

Esensten, J.H.; Tsytsykova, A.V.; Lopez-Rodriquez, C.; Ligeiro, F.A.; Rao, A.; Goldfeld, A.E.; "NFAT5 binds to the TNF promoter distinctly from NFATp, c, 3 and 4, and activates TNF transcription during hypertonic stress alone." Nucleic Acids Res. 2005 Jul 12; 33(12):3845-54.