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Zalatan Lab website

Assistant Professor of Chemistry - University of Washington

Past: Postdoctoral Fellow (2008-2014)


2008 - 2014
Postdoctoral Fellow
University of California, San Francisco

2002 - 2008
Ph.D., Chemistry
Stanford University

1998 - 2002
A.B., Biochemical Sciences
Harvard University

Fellowships and Awards

Burroughs Wellcome Fund Career Award at the Scientific Interface, 2012-present
Damon Runyon Postdoctoral Fellowship, 2009-2011
Hertz Foundation Graduate Fellowship, 2002-2007


Zalatan, J.G.*, Coyle, S.M.*, Rajan, S., Sidhu, S.S., and Lim, W.A. "Conformational control of the Ste5 scaffold protein insulates against MAP kinase misactivation." Science 337 (6099): 1218-1222 (2012).

Good, M.C., Zalatan, J.G., and Lim, W.A. "Scaffold proteins: hubs for controlling the flow of cellular information." Science 332, 680-6 (2011). (Abstract)

Lassila, J.K.,* Zalatan, J.G.,* and Herschlag D. "Biological phosphoryl-transfer reactions: Understanding mechanism and catalysis." Annu. Rev. Biochem. 80, 669-702 (2011).

Zalatan, J. G. and Herschlag, D. "The Far Reaches of Enzymology." Nature Chemical Biology 5, 516-520 (2009).

Zalatan, J. G., Fenn, T. D., and Herschlag, D. "Comparative Enzymology in the Alkaline Phosphatase Superfamily to Determine the Catalytic Role of an Active Site Metal Ion." Journal of Molecular Biology 384, 1174-1189 (2008).

O'Brien, P. J., Lassila, J. K., Fenn, T. D., Zalatan, J. G., and Herschlag, D. "Arginine Coordination in Enzymatic Phosphoryl Transfer: Evaluation of the Effect of Arg166 Mutations in Escherichia coli Alkaline Phosphatase." Biochemistry 47, 7663-7672 (2008).

Zalatan, J. G., Catrina, I., Mitchell, R., Grzyska, P. K., O'Brien, P. J., Herschlag, D., and Hengge, A. C. "Kinetic isotope effects for alkaline phosphatase reactions: Implications for the role of active site metal ions in catalysis." Journal of the American Chemical Society 129, 9789-9798 (2007).

Catrina, I., O'Brien, P. J., Purcell, J., Nikolic-Hughes, I., Zalatan, J. G., Hengge, A. C., and Herschlag, D. "Probing the origin of the compromised catalysis of E. coli alkaline phosphatase in its promiscuous sulfatase reaction." Journal of the American Chemical Society 129, 5760-5765 (2007).

Zalatan, J. G., Fenn, T. D., Brunger, A. T., and Herschlag, D. "Structural and functional comparisons of nucleotide pyrophosphatase/phosphodiesterase and alkaline phosphatase: Implications for mechanism and evolution." Biochemistry 45, 9788-9803 (2006).

Zalatan, J. G. and Herschlag, D. "Alkaline phosphatase mono- and diesterase reactions: Comparative transition state analysis." Journal of the American Chemical Society 129, 1293-1303 (2006).