Geoffrey | O'Donoghue


Postdoctoral Fellow


2014 - present

Postdoctoral Fellow
University of California, San Francisco

2008 - 2013
Ph.D. in Chemistry
University of California, Berkeley

2002 - 2006
B.A. in Chemistry
Williams College

Research Interests

Molecular organization and biophysics at cell:cell interfaces | T cell signaling | T cell therapeutics

Fellowships and Awards

2015 F32 Ruth L. Kirschstein National Reseaarch Service Award (NIH)
2006 Frank C. Goodrich Award for excellence in chemistry research (Williams College)


Pielak, R.M.*; O'Donoghue, G.P.*; Lin, J.J.*, Alfieri, K.N., Fay, N.C., Low-Nam, S.T., Groves, J.T.; Early T cell receptor signals globally modulate ligand:receptor affinities during antigen discrimination. Proc Natl Acad Sci U S A., in press. (* denotes equal authorship)

Hartman, N.*; Kai, H.*; Liu, E.Y.*; Fay, N.; Yu, Y.; Lohmüller, T.; O'Donoghue, G.P.; Groves, J.T.; Size-based chromatography of signaling clusters in a living cell membrane. Nano Letters, in press. (* denotes equal authorship)

O'Donoghue, G.P.*; Pielak, R.M.*; Smoligovets, A.A.; Lin, J.J.; Groves, J.T.; Direct single molecule measurement of TCR triggering by agonist pMHC in living primary T cells; eLife 2013;2:e00778 (* denotes equal authorship)

Lau, C.; Mirkovic, J.; Yu, C.C.; O'Donoghue, G.P.; et. al.; Early detection of high-grade squamous intraepithelial lesions in the cervix with quantitative spectroscopic imaging. J. Biomed. Opt. 2013; 18(7):76013

Belardi, B.; O'Donoghue, G.P.; Smith, A.W.; Groves, J.T.; Bertozzi, C.R.; Investigating Cell Surface Galectin-Mediated Cross-Linking on Glycoengineered Cells; J. Am. Chem. Soc. 2012,134, 9549-9552

Lohmüller, T.; Triffo, S.; O'Donoghue, G.P.; Xiu, Q.; Coyle, M.P.; Groves, J.T.; Supported Membranes Embedded with Fixed Arrays of Gold Nanoparticles; Nano Letters 11 (2011) 4912-4918

Yu, C.C.; Lau, C.; O'Donoghue, G.P.; Mirkovic, J.; McGee, S.; Galindo, L.; Elackattu, A.; Stier, E.; Grillone, G.; Badizadegan, K.; Dasari, R.R.; Feld, M.S.; Quantitative spectroscopic imaging for non-invasive early cancer detection; Optics Express 16 (2008) 16227-16239

Saar, B.G.; O'Donoghue, G.P.; Steeves, A.H.; Thoman, J.W.; Evidence for a blue-shifting intramolecular hydrogen bond in the vibrational overtone spectrum of 1Hnonafluorobutane; Chemical Physics Letters 417 (2006) 159-163